D1T - Ling pIL-1 processing by calpain and the release of mature IL- http://d1t.com/story.php?title=ling-pil-1-processing-by-calpain-and-the-release-of-mature-il--8 Ling pIL-1 processing by calpain and the release of mature IL-1. However, Gross et al.137 showed that caspase-1 dependency for IL-1 secretion can differ depending on the stimulus and the targeted inflammasomes and does not seem to require the protease activity of caspase-1. IL-1 secretion may therefore rely on redundant parallel pathways. In fact, elevated intracellular Ca2+ triggers IL-1 secretio Wed, 11 Sep 2019 11:11:45 UTC en