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Cancerous cells secrete α-N-acetylgalactosaminidase (NaGalase) into the blood stream, resulting in deglycosylation of serum vitamin D3-binding protein (known as Gc protein), which is a precursor for macrophage triggering element (MAF). Incubation of Gc protein with debilitated β-galactosidase and sialidase generates the most powerful macrophage triggering element (designated GcMAF). Administration
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Antibody to HLA, or the Fab fragment, or the F(ab)2 fragment for 1 h, and the amount of released VWF was measured (n 3 SD). (B) Cross-linked Fab fragment activates exocytosis. HAEC were incubated with the Fab fragment of antibody to HLA, and then mouse F(ab)2 antibody to human Fab was added for 1 h to cross-link Fab monomers (n 3 SD; *, P 0.05 vs. control).Fig. 6. Antibody activates leukocyte adhe
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